The Fremantle skipper was subbed out in the second quarter of last Thursday night’s match against Carlton with concussion.
Pavlich trained lightly on Tuesday morning, but Lyon told Channel 7 the club legend would most likely miss the clash against the Cats.
“He failed a cognitive state (test), so I’m planning for him not to play until he proves otherwise,” he said.
Fremantle’s captain played his 300th AFL game in round 9 against Geelong earlier this season.